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Understanding Our Crucial Cytochrome P450 Enzymes Continued from page 42 bilirubin tests—especially if you have now know, you can react to—such is any yellowing of skin or eyes, or if not the case with energy balancing.’ pronounced like "Zheel-bear".) This you've seen that your stools are Everything has its benefits and its mutation or defect is the lack of green or yellow when you are feeling — limitations. co about 70 per cent of the normal _ sickest. ability of one of the liver's Cut down or eliminate fats, oils, About the Author: detoxification mechanisms. This is dairy, meats and particular foods that the liver's Phase II glucuronidation affect this liver detoxification cycle. alilie.. reota 4h sade. 26 Steven Rochlitz, PhD, was originally a physics professor. For the past 32 years pronounced like "Zheel-bear".) This mutation or defect is the lack of about 70 per cent of the normal ability of one of the liver's detoxification mechanisms. This is the liver's Phase II glucuronidation ability. It is the addition of glucuronic acid to bilirubin—a breakdown product of haemoglobin. Other lipophilic compounds may also not be processed properly. This adding of glucuronic acid is called "conjugation" or, here, "glucuronidation". Gilbert's sufferers also often have several other linked mutations. Bilirubin can build up to toxic levels, but this weakness in the liver's Phase II detoxification system also means that drugs, foods, hormones and_ environmental chemicals can cause illness in Gilbert's sufferers. GS sufferers have elevated unconjugated bilirubin blood levels. | think, though, that the upper normal limit may be set too high, as many people unknowingly have GS. Get tested also for total and conjugated bilirubin. Faulty glucuronidation may be involved in "reacting" to acetominophen, morphine, benzodiazepines, aspirin, vanillin, benzoates, fish oils, citrus, birth control pills or tobacco. GS can cause elevated bilirubin blood levels, which during flare-ups can result in a slight yellowish tinge to the skin or sclera in the eyes and in intermittent, benign, non-hepatitis jaundice. Gilbert's syndrome is poorly understood. Its sufferers are said to have many and varied complaints "not attributable to their genetic defect". GS sufferers have many symptoms in common with CFS or MCS sufferers. Gastrointestinal, neurological, muscular and other complaints abound. Often there is also light sensitivity, indicating here a possible CYP450 problem. If you have intolerance (or addiction in the early stages) to fats or oils, get the Cut down or eliminate fats, oils, About the Author: dairy, meats and particular foods that Steven Rochlitz, PhD, was originally a affect this liver detoxification cycle. > > gay physics professor. For the past 32 years he has researched chronic and environmental illnesses and taught his seminars across the world. His unique system incorporates breakthroughs in energy kinesiology, nutrition and EMF Effects and Energy Balancing Finally, | note that the effects of electromagnetic fields (EMF) on CYP450 enzymes have been documented. These effects may be the tip of the iceberg, human ecology. Dr Rochlitz is the and another reason for the current author of 10 books (see reviews in explosion of — chronic and NEXUS 19/04, 19/02, 18/02). This environmental illness. : article, his sixth contribution to There is much energy balancing NEXUS, is partially excerpted from his you can do for your liver, small hook Porphyria: The Ultimate Cause of intestine and other organs. Common, Chronic and Environmental Use applied kinesiology (AK), Or Jjnesses, which has been cited as a acupressure, acupuncture OF significant health breakthrough. reflexology. Some AK methods— Further research is at his website including Chapman's neurolymphatic http://www.wellatlast.com. Dr Rochlitz and Bennett's neurovascular can be emailed at info@wellatlast.com. reflexes—can be done many times per day. They will increase lymph Endnotes and blood flow to the organs. 1. Scott, Gayle and Elmer, Gary, Also beneficial may be lymph -ypdate on Natural Product-Drug massage, exercise, magnetic lymph interactions: St John's Wort", American cleansing and Rife machine therapy. Journal of Health-System Pharmacy 2002; We have seen that anomalies in the 59(4):339, http://tinyurl.com/77aqzms cytochrome P450 enzyme system 9. Bradford, L. DiAnne, "CYP2D6 account for our individual reactions ajjele frequency in European to foods, chemicals, drugs and even Caucasians, Asians, Africans and their our own hormones. Much of chronic descendants", Pharmacogenomics 2002 and/or environmental illness and Mar; 3(2):229-243 also the ageing process are involved 3. Rochlitz, Steven, Porphyria: The with these enzymes. If we suffer from — Ujtimate Cause of Common, Chronic, and deficiency or defect of one or more of — Environmental Illnesses. With these enzymes, eating—and rotating— Breakthroughs in Diet, Supplements, and organic foods, avoiding toxins in the Energy Balancing, 2nd edition, ISBN 0- air, food and water, and minimising 94596-59-0, EMF exposure are important. http://www.wellatlast.com Liposomal, or acetyl-, glutathione 4, Wiaderkiewicz, R. et al., "The Effect can help as well. ___ of Electromagnetic Fields on the Get tested for everything before it Cytochrome P450 System in Rat Liver goes into your body. If you find that {nduced by Phenobarbital”, April 2006, the testing was not accurate, find http://tinyurl.com/7rvtjpx another source. Learn various forms 5, Rochlitz, Steven, Allergies and of energy balancing to regain OF Candida: with the Physicist's Rapid retain your health, instead of Solution, 5th edition, ISBN 0-945262- assuming that only pills can achieve 48-5, http:/Avww.wellatlast.com those goals. Unlike drugs or even (includes 40 energy-balancing natural supplements—which, as you techniques and food-family lists) Endnotes 1. Scott, Gayle and Elmer, Gary, "Update on Natural Product—Drug Interactions: St John's Wort", American Journal of Health-System Pharmacy 2002, 59(4):339, http://tinyurl.com/77aqzms 2. Bradford, L. DiAnne, "CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants", Pharmacogenomics 2002 Mar; 3(2):229-243 3. Rochlitz, Steven, Porphyria: The Ultimate Cause of Common, Chronic, and Environmental Illnesses. With Breakthroughs in Diet, Supplements, and Energy Balancing, 2nd edition, ISBN 0- 945262-59-0, http://www.wellatlast.com 4. Wiaderkiewicz, R. et al., "The Effect of Electromagnetic Fields on the Cytochrome P450 System in Rat Liver nduced by Phenobarbital", April 2006, http://tinyurl.com/7rvtjpx 5. Rochlitz, Steven, Allergies and Candida: with the Physicist's Rapid Solution, 5th edition, ISBN 0-945262- 48-5, http://www.wellatlast.com (includes 40 energy-balancing techniques and food-family lists) 80 * NEXUS JUNE - JULY 2012 Continued from page 42 www.nexusmagazine.com