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The Liver’s Detoxifying Phases histamine. This can lead to metabolic toxicity, Many toxins are fat soluble, and it is the liver's job to inflammatory conditions and allergy-like disorders. make them water soluble so that they can be eliminated People with underactive CYP450 enzymes can be more via the kidneys or else via bile/stool. Phase I is mostly susceptible to caffeine intolerance, drug intolerance, cytochrome P450—mediated detoxification. These multiple chemical sensitivity (MCS) and universal food reactions add oxygen (oxidation) and are also called reactivity. Inhibition of CYP450s can be caused by low "bioactivation". But this phase actually creates free caloric intake or fasting, protein deficiency, radicals and can even make some chemicals phosphatidylcholine deficiency, antihistamines, carcinogenic. If the liver's subsequent Phase II is cimetidine, naringenin in grapefruit, vitamin C and A underfunctioning, many of the free radicals and potentia deficiencies, and bacterial endotoxins. carcinogens created via the Phase | reactions can ge If Phase I is overactive, obviously decreasing the toxic into the bloodstream and cause harm and illness. Some _ burden on the body is key. Cutting down on protein and labs test for Phase | and II activity as well as for indoles (in cruciferous vegetables) can also help glutathione levels. This may involve ingesting aspirin, | normalise a hyperactive Phase I. The best current solution acetaminophen and caffeine. Then blood, urine and may be to avoid xenobiotics, as exposure leads to the body's saliva are taken to assay how well and how quickly the —_ attempts to create more CYP450s. This apparently only ends liver processes these chemicals. Phase I can be up yielding more porphyrins and perhaps less- inhibited by grapefruit (naringenin), some herbs, spices detoxifying CYP450s in some people.’ Indeed, the and drugs. Other herbs can complexity of the CYP450 enhance Phase I. Some Phase | enzymes is indicated by the fact in ermediate metabolites are Chronic toxic exposure that a single food, or even a food similar or identical to sedative . component, may induce some compounds. They an rause causes creation of more cre enzymes and inhibit others. atigue, as in CFS. Aldehydes The various interacting parameters— also are produced in Phase | CYP450 enzymes, induction, inhibition, half-life—of the reactions, and their activity can CYP450 system at least partially There is significant individual ll | d h 9 account for universal food reactivity as variability here, since some 57 eventua y lea to epatic well as for food addiction and known genes—each with many and other tissue damage. withdrawal. variations, some over 100— A low-fat, organic diet can be code for about this same crucial for improving CYP450/ number of known CYP450 Phase | functioning. Try to avoid enzymes. Thus there is a tremendous variability in all toxic substances in air, water and food. Special liver- mankind's reactions to foods, drugs, environmental enabling nutrients like glutathione and other chemicals, our own hormones, etc. There is also a wide — antioxidants may help. The newer liposomal or acetyl variation in the amount of CYP450 enzymes in people. — forms of glutathione are recommended here. Ideally, This can account for small amounts of compounds in —_ muscle-test every food and supplement before ingesting. ood or air causing illness in some. Failure to do this with a good and accurate kinesiologist With exposure to toxic substances, the activity and (or to become one yourself, or for your partner to number of specific CYP450 enzymes that take up these become one) is a leading reason for the failure of specific toxic substances—and similarly our own chronically ill people to get well. ormones and food compounds—increase. Again, this is called "induction". Also induced are other hepatic _ Gilbert’s Syndrome and Intolerance to Fats detoxification enzymes involved in conjugation (Phase Above | noted that CYPIA is involved in bilirubin I), namely sulphur transferase, and in acetylation and metabolism. CYP2E1 is also involved in metabolising sulphation. Chronic toxic exposure causes the creation lipid peroxide radicals produced from fats. Now, many of more CYP450 enzymes, and their activity can people with chronic and/or environmental illness eventually lead to hepatic and other tissue damage. If recognise that the onset of it included intolerance to oxic exposure is too great or too frequent, the fatty foods. They may have noted yellow or green stools, conjugating nutrients—glutathione peroxidase, feeling sick or having abdominal pain or other glutathione reductase, vitamin E, vitamin C, carotenes, complaints as a result of eating fatty foods. Five to 10 per superoxide dismutase (SOD)—may become depleted, — cent of humanity is said to have an hereditary mutation causing eading to peroxidation and tissue damage, but the them to have Gilbert's syndrome (GS). The percentage is much opposite effect can be harmful too. higher for people with chronic inflammatory illness, though most will This is part of the complexity of the CYP450 system. never get tested for GS. (Gilbert was French, so his name is Deficient, inhibited and/or porphyric CYP450s may make it more difficult to clear hormones and inflammatory compounds, e.g., Continued on page 80 Chronic toxic exposure causes creation of more CYP450 enzymes, and their activity can eventually lead to hepatic and other tissue damage. Gilbert’s Syndrome and Intolerance to Fats Above | noted that CYPIA is involved in bilirubin metabolism. CYP2EI is also involved in metabolising lipid peroxide radicals produced from fats. Now, many people with chronic and/or environmental illness recognise that the onset of it included intolerance to fatty foods. They may have noted yellow or green stools, feeling sick or having abdominal pain or other complaints as a result of eating fatty foods. Five to 10 per cent of humanity is said to have an hereditary mutation causing them to have Gilbert's syndrome (GS). The percentage is much higher for people with chronic inflammatory illness, though most will never get tested for GS. (Gilbert was French, so his name is 42 * NEXUS JUNE - JULY 2012 Continued on page 80 www.nexusmagazine.com