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This can explain why the withdrawal phase from a food So, whether for drugs or supplements/herbs, the asts about four or five days. Stopping and preventing “logic” of saying "If the lower dose didn't help you, just urther induction of specific CYP450 enzymes is take more" can be harmful, even fatal. CYP450 uptake accomplished by adhering to the Rotary Diversified Diet | accounts for 75 per cent of drug metabolism in the body. (RDD). One does not eat the same food again until four It is admitted that in the USA alone, over 100,000 days later and even avoids foods in the same family for people per year die from adverse drug reactions. Much wo days. While allergists first proposed this some 75 __ of these are said to be from interactions between drug- years ago, this may be the first accurate explanation for it. | induced CYP450 enzymes, which we will shortly discuss. Everyone with any inflammatory or allergy-like illness Some people report lifelong problems after taking should try it. certain drugs. These include birth control pills, Many people with chronic illness know some of these _antidepression drugs, antipsychotic drugs, anti-epileptic hings intrinsically, but most often the full extent or | drugs—indeed, any drug. Sulfonal, the first popular nature of the problem is not yet known. Someone may — sulphur-containing drug used in the 1880s, caused variously be avoiding only one of the following adverse and, likely, porphyric reactions in some 14 per components in foods: gluten/gliadin, sulphur cent of those who took it. Likewise, any toxic exposure compounds, salicylates, oxalates, may overload the CYP450 enzymes ectins, sialic acid, advanced glycation and other systems and cause lifelong end-products (AGEs), belladonna problems. Chemotherapy for cancer alkaloids (nightshades) or others. But The sickest people patients is known to have done this, people with these problems may need and sometimes causes lifelong o avoid more than one of these are often those intolerance to the sun. Recall that groups. Indeed, some people react to . he CYP450 enzymes got their name oods in all these groups. Then there who are eating because they absorb blue-indigo may be little left to eat. However, we only 3-5 foods ight, and anyone who is sun or light can utilise our knowledge of the half- sensitive may have an anomaly in ife effect of the CYP450 enzymes—or every day. Also hese enzymes causing this he knowledge that has come from among the sickest sensitivity. Pesticide exposure is environmental physicians—and that is nown to have caused lifelong © rotate all foods, else safe foods may are those who are chronic illness, in part via CYP450 soon cause adverse reactions. taking drugs or anomalies; and mercury Since most of these reactions are | dail compounds may have the not permanent or true allergic supp’ ements ly greatest capacity to create reactions, many previously unsafe that they are lifelong defect and/or deficiency foods—but not all—may be a in numerous CYP450 enzymes. tolerated on a rotating basis. The unknowingly Again, this may really be sickest people are often those who reacting to porphyria. are eating only 3-5 foods every day. Also among the sickest are every day. CYP Detoxifies Toxins in Plants Virtually all living entities, from simple viruses to single-celled those who are taking drugs or supplements daily that they are unknowingly reacting to every day. plants and animals to higher The danger of reacting to drugs mammals, have CYP450 or anaesthetics is illustrated by the enzymes. Some mammals have following. As most physicians know little about all this— = more than the 50-60 that humans have. Mice, for or don't act accordingly—when a prescribed drug does example, have 101 known CYPs. (I will henceforth drop not have the desired effect, many physicians will then the "450".) On the evolutionary timeline, the gene for merely say, "Well, let's try you on a higher dose or a__— CYP is thought to have existed for more then 3.5 billion longer period of time". Sometimes this may actually be years. As plants and animals evolved together, it is correct (from their point of view), as it is possible to have — thought that with more higher animals around to eat an overabundance of specific CYP450 enzymes that plants, the plants began to create more toxic process a drug. Then more of the drug is needed to compounds within them, and animals then had to overcome the rapid metabolising of it before it can take evolve with more CYP enzymes to survive ingesting the effect. However, if the drug was first ineffective and was __ evolving plants’ toxins. overridden by side-effects, it may be an indication of a Recently, in addition to detoxifying ingested or deficiency in the specific CYP450s needed to process it. inhaled toxins and metabolising various compounds in Then giving a higher dose may have drastic the body, CYP was found to be involved in vascular consequences. autoregulation, particularly in the brain. The sickest people are often those who are eating only 3-5 foods every day. Also among the sickest are those who are taking drugs or supplements daily that they are unknowingly reacting to every day. consequences. JUNE - JULY 2012 NEXUS ¢ 39 www.nexusmagazine.com