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with food reactivity comprise environmental illness — with this possible link to porphyria, causing MCD, as (El). Heuser stated that either MCD or porphyria may be have hypothesised. This large set of enzymes, the so- causative in MCS. In 2009, the first edition of my called superfamily CYP450 3A, may be the mos Porphyria book was published. | believe that with this © common link between porphyria and MCD. These book I became the first to assert that the two haem proteins may be defective and/or deficient in illnesses—mast cell disease and porphyria—are linked — porphyrics, and thus cells that have a high amount o and that people with MCS or EI may have both them will malfunction sooner or later, resulting in MCD conditions, and thus this is much deeper and may not __ in these people. be an "either/or" matter.’ If both conditions are Macroscopically, this may manifest in fascinating and present, it is likely that porphyria causes a secondary observable ways. When stressed out, the person may break MCD. Perhaps years of having hidden porphyria may out in hives or a rash or may swell up. The mechanism | can now later result in MCD. The mechanism will be detailed — explain for the first time. If this person is a hidden shortly. However, for now I note that physicians — porphyric, any extra stress involves elevated adrena treating either of these two maladies may not realise hormones which are processed by the CYP450 3A the existence of the other; that is, an attack of one may be enzymes. However, anything that attempts to up- an attack of the other instead of, or in regulate haem proteins too rapidly addition to, an isolated attack of the first results in excess porphyrins and often condition. in subsequent deficiency of these Of the two conditions, porphyria enzymes—and in dysfunction of the cells, remains the one less likely to be including mast cells, which contain many of known due to the current state of I believe that with them. Thus they may degranulate too poor and/or corrupt diagnostic 0 readily when the (hidden) porphyric is testing, while testing for MCD is this book I became stressed. You may see a very nervous simpler and may be more accurate. the first to assert person—with a possible porphyria Skin symptoms may be quite visible th t th t reaction—also manifesting a rash or and undeniable—but only in the later a ie two other skin problem. Indeed, stages. Some of the skin conditions illnesses— angioedema was once called may even be construed as one of the : angioneurotic oedema because when skin porphyrias. However, MCD may mast cell disease the patient was very nervous, s/he first occur in the gastrointestinal tract, and porphyria— would get these large swollen and so skin anomalies and skin tests li k d d h tissues. Unfortunately the “high may not manifest until a later time. are linked and that anxiety" was thought of as being Recall that porphyria—to people with MCS “mental” and not biochemical, or which 20 per cent of mankind else the porphyria connection may be genetically predisposed or EI may have might have been hypothesised —entails the body improperly both conditions sooner. Unfortunately, some physicians incorrectly apply logic and simplistically say to patients; "You can't have two rare diseases porphyria and MCD]." But assert that (1) neither is rare and 2) they are linked, as I have and insufficiently creating the protein haem. While everyone nows that haem is in aemoglobin, it is less known hat some 40 per cent of the body's haem goes into making he cytochrome P450 (CYP450) enzymes. These enzymes are involved in numerous _ explained above. metabolic functions, including detoxifying external Another aspect of the possible interplay between chemicals (e.g., drugs) and internal chemicals, hidden porphyria and MCD is that histamine is also processing vitamins and making our hormones. There processed by one or more CYP450 enzymes. Thus norma are some 51 known CYP450 enzymes in humans. levels of histamine can cause problems in the (hidden Different CYP450 enzymes may be in different tissues — porphyric because histamine is not processed properly and occur in very differing amounts. and may also result in excess porphyrins being The cytochrome P450 3A enzymes have been found in released. some mast cells. These CYP450 3A enzymes metabolise steroid hormones, vitamin D, cholesterol _ Foods and Histamine Toxicity and many xenobiotics, and are GABA receptor related A related histamine matter is that some foods (GABA, gamma-aminobutyric acid, is an inhibitory contain histamine or its biochemical precursor or neurotransmitter). Thus MCS, EMFS, hormonal — known histamine-releasing compounds. Foods high in dysfunction and stress intolerance may be involved polyamines can be very problematic for allergic people. illnesses— and porphyria— are linked and that people with MCS or El] may have both conditions... Se ne ed explained above. Another aspect of the possible interplay between hidden porphyria and MCD is that histamine is also processed by one or more CYP450 enzymes. Thus normal levels of histamine can cause problems in the (hidden) porphyric because histamine is not processed properly and may also result in excess porphyrins being released. Foods and Histamine Toxicity A related histamine matter is that some foods contain histamine or its biochemical precursor or known histamine-releasing compounds. Foods high in polyamines can be very problematic for allergic people. NEXUS ¢ 39 I believe that with this book | became the first to assert that the two mast cell disease FEBRUARY - MARCH 2012 www.nexusmagazine.com