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Recent research indicates that many things can cause BBB permeability: hidden heart defects, stress, heat, allergies, nutritional deficiencies, toxins and other factors. | have hypothesised that if the common heart defect called patent foramen ovale (PFO)—which as many as one out of every three people may have—is present, it may lead to BBB permeability and thus a susceptibility or an intolerance to even small amounts of excess porphyrins. The PFO is an atrial septal defect. It is a hole or tunnel between the two upper chambers of the heart that did not close properly in one-third of humanity. The PFO has been linked to causing migraines (especially if aura is present) and strokes. Recent research indicates that many things can cause chronic porphyria and chronic and/or environmental BBB permeability: hidden heart defects, stress, heat, _ illness, you can see how the PTB may all come together allergies, nutritional deficiencies, toxins and other _ to fight at this last frontier. Indeed, the PTB still do not actors. I have hypothesised that if the common heart even want to recognise MCS as a legitimate illness. defect called patent foramen ovale (PFO)—which as_ Some still claim that very small levels of xenobiotics many as one out of every three people may have—is can't possibly make anyone sick, that the illness is present, it may lead to BBB permeability and thus a___ merely psychological, and that, whatever it is, it isn't a susceptibility or an intolerance to even small amounts of orm of porphyria. This is despite the recent scientific excess porphyrins. The PFO is an atrial septal defect. It inding that parts per trillion'* have caused illness in other is a hole or tunnel between the two upper chambers of | mammals, and that chronic toxic exposure has been he heart that did not close properly in one-third of — proven to cause chronic porphyria.” umanity. The PFO has been linked to causing When Drs Downey and Morton and numerous other migraines (especially if aura is present) and strokes. physicians and bona fide scientists published articles in the 1990s, demonstrating that 70 to 90 per cent of those with Genetics, Toxic Exposure and the Powers That Be MCS have some form of porphyria, the PTB countered by Why is it that only some people become chronically ill creating claims that not just abnormally high levels of and/or allergic after mercury, mould, pesticide or other — porphyrins denote the disease, but that some arbitrarily oxic exposure, or from Candida declared, much higher abnormal or other overgrowth or infection? evel of porphyrins must be The matter of porphyria seems to : ang ound before someone can either explain this well. If the person ...there is a separate political receive a porphyria diagnosis or as the underlying genetic defect, 1 be allowed to use it as a basis for any additional toxin in the sphere regarding the matter a disability benefit. This is system can put them over their of just how many people despite such factors as | have clevated porphyria state whereby | Feally acquire a chronic BBB permesbilty exists then a hey are both more sick and more form of porphyria after larger percentage of porphyrins may get into the brain. Due to the fact that people are likely to have other underlying medical conditions, reactive ("allergic") to other hings. Two physicians have demonstrated the micro- organism overgrowth connection a toxic exposure. ‘0 chronic porphyria in their arthritic patients. Many were created a terminology that takes this into account. In ound to harbour the Chlamydia pneumoniae bacterium analogy with diabetes type IJ, | have called this chronically, and many also showed that this then caused Porphyria Type II, with numerous sub-classifications hem to acquire a form of porphyria."* Heavy metals, hat correlate with the other medical conditions which moulds, pesticides or chemicals may also permanently he person is found to have. These other factors can damage DNA, leaving people in a permanently elevated interact and cause any abnormally high level of state of porphyria—and/or suffering from MCS, EMFS, porphyrins to be more causative of symptoms than ood reactivity and some "new" chronic illness. otherwise might be the case. These other conditions As the wise reader might surmise, there is a separate include more than one type of porphyria (among the political sphere regarding the matter of just how many _ eight), pyroluria, mast cell disease,’° BBB permeability, people really acquire a chronic form of porphyria after a ung disease (asthma, chronic obstructive pulmonary oxic exposure. When porphyria expert William Morton, disease, reactive airway disease) and heart disease MD, PhD, saw many patients suffering from MCS and PFO," mitral valve prolapse and other conditions). porphyria and then helped hundreds of them to get on If you can, get tested for porphyria and all the other disability benefits, his licence was revoked. (He chose _ relevant conditions that are cited in this article, if you not to fight his medical review board in Oregon, and aven't already. Many people also have hidden asthma, retired from seeing patients.) ood reactions, sleep apnoea, hiatal hernia/vagus nerve The matter of chronic porphyria with concomitant disorder, defective or deficient cytochrome P450 chronic and/or environmental illness resulting from a — enzymes'* and other problems that can be helped. toxic exposure is being vigorously and viciously fought This is an age when, if the least-elevated level of by the Powers That Be (PTB). Recall that it took over 70 cholesterol is found, the PTB will swoop down on a years for asbestos to be recognised universally as _ patient and try to dictate a lifetime of drug-taking (often carcinogenic. During that interval, numerous scientists causing problems far worse than what the drug is and physicians, in the pockets of industry, swore that it wasn't. As many different types of toxins may result in Continued on page 78 ... there is a separate political sphere regarding the matter of just how many people really acquire a chronic form of porphyria after a toxic exposure. 36 * NEXUS Continued on page 78 DECEMBER 2010 - JANUARY 2011 www.nexusmagazine.com