Nexus - 0704 - New Times Magazine-pages

Page Content (OCR)

Excitotoxins: Dai s Food Additives i sclerosis", Neurol. Sci. 129:81-84, 1995. 39. Fahn, S., "A pilot trial of high-dose alpha- Continued from page 81 31. Gerlach, M., Ben-Shachar, D. et al., tocopherol and ascorbate in early Parkinson's 17:2653-2657, 1997. “Altered brain metabolism of iron as acause of disease", Ann. Neurol. 32:5128-S132, 1992. 23. Jenner, P. et al., "Oxidative stress as a neurodegenerative diseases", J. Neurochem. 40. Niki, E., "Interactions of ascorbate and cause of nigral cell death in Parkinson's dis- 63:793-807, 1994. alpha-tocopherol", Third Conference of ease and incidental Lewy body disease", Ann. 32. Dawson, V.L., Dawson, T.M. et al., Vitamin C, Burns, E.T. (ed.), Ann. NY Acad. Neurol. 32:282-287, 1992. "Mechanisms of nitric oxide-mediated neuro- _— Sci. 498:186-199, 1987. 24. Griffiths, P.D. and Crossman, A.R., toxicity in primary brain cultures", J. Neurosci. 41. Beal, M.F., Hyman, B.T. and Koroschetz, "Distribution of iron in the basal ganglion and = —-13:2651-2661, 1993. W., "Do defects in mitochondrial energy neocortex in Parkinson's disease and 33. Williams, L.R., "Oxidative stress, age- metabolism underlie the pathology of neu- Alzheimer's disease", Dementia 2:61-65, related neurodegeneration, and the potential rodegenerative diseases?", Trends in Neurosci. 1993. for neurotrophic treatment", Cerebrovasc. 16:125-131, 1993. 25. Bolanos, J.P., Almeida, A. et al., "Nitric Brain Metab. Rey. 7:55-73, 1995. 42. Pall, H.S., Blake, D.R. et al., "Raised cere- oxide-mediated mitochondrial damage in the 34. Domenico, E., Pellegrini-Giampietro et brospinal fluid copper concentration in brain: mechanisms and implications for neu- al., "Excitatory amino acid release and free Parkinson's disease", Lancet Aug 1:238- rodegenerative diseases", J. Neurochem. radical formation may cooperate in the gene- 2411987. 68:2227-2240, 1997. sis of ischemia-induced neuronal damage", J. 43. Sorg, O., Horn, T.F. et al., "Inhibition of 26. Dexter, D.T. et al., "Increased iron con- Neurosci. 10:1035-1041, 1990. astrocyte glutamate uptake by reactive oxygen tent in post-mortem Parkinsonian brain", 35. Mundy, W.R., Freudenrich, T.M. and species: role of antioxidant enzymes", Mol. Lancet ii:219-220, 1987. Kodavanti, P.R., "Aluminum potentiates gluta- Med. 7:431-440, 1997. 27. Hirsch, E.C., Brandel, J.P. et al., "Iron and — mate-induced calcium accumulation and iron- . aluminum increase in the substantia nigra of induced oxygen free radical formation in pri- Editor's Note: patients with Parkinson's disease: an X-ray mary neuronal cultures", Mol. Chem. This article is reproduced courtesy of Dr microanalysis", J. Neurochem. 56:446-451, Neuropathol. 32:41-57, 1997. Russell Blaylock and was first published in 1991. 36. Aarala, J.T., Loikkanen, J.J. et al., "Lead Medical Sentinel (vol. 4, no. 6, Nov-Dec 28. Logroscino, G., Marder, K., Graziano, J. et amplifies glutamate-induced oxidative stress", 1999), the bimonthly peer-reviewed journal of al., "Altered systemic iron metabolism in Free Radical Biol. Med. 19:689-693, 1995. the Association of American Physicians and Parkinson's disease", Neurology 49:714-717, 37. Lipton, S.A. and Nicotera, P., "Calcium, Surgeons (AAPS) [Hacienda Publishing, Inc., 1997. free radicals and excitotoxins in neuronal PO Box 13648, Macon, GA 31208-3648, 29. Schapira, A.H.V. et al., "Mitochondrial apoptosis", Cell Calcium 23:165-171, 1998. USA, tel (912) 757 9873, fax (912) 757 9725, complex | deficiency in Parkinson's disease", J. 38. Murphey, T.H. et al., "Immature cortical e-mail hfaria@mindspring.com, website Neurochem. 54:823-827, 1990. neurons are uniquely sensitive to glutamate www.haciendapub.com]. 30. Bergerson, C., "Oxidative stress: Its role toxicity by inhibition of cystine uptake", 7 . in the pathogenesis of amyotrophic lateral J. FASEB 6:1624-1633, 1990. Continued next issue ... sclerosis", Neurol. Sci. 129:81-84, 1995. 31. Gerlach, M., Ben-Shachar, D. et al., “Altered brain metabolism of iron as a cause of neurodegenerative diseases", J. Neurochem. 63:793-807, 1994. 32. Dawson, V.L., Dawson, T.M. et al., "Mechanisms of nitric oxide-mediated neuro- toxicity in primary brain cultures", J. Neurosci. 13:2651-2661, 1993. 33. Williams, L.R., "Oxidative stress, age- related neurodegeneration, and the potential for neurotrophic treatment", Cerebrovasc. Brain Metab. Rev. 7:55-73, 1995. 34. Domenico, E., Pellegrini-Giampietro et al., "Excitatory amino acid release and free radical formation may cooperate in the gene- sis of ischemia-induced neuronal damage", J. Neurosci. 10:1035-1041, 1990. 35. Mundy, W.R., Freudenrich, T.M. and Kodavanti, P.R., "Aluminum potentiates gluta- mate-induced calcium accumulation and iron- induced oxygen free radical formation in pri- mary neuronal cultures", Mol. Chem. Neuropathol. 32:41-57, 1997. 36. Aarala, J.T., Loikkanen, J.J. et al., "Lead amplifies glutamate-induced oxidative stress", Free Radical Biol. Med. 19:689-693, 1995. 37. Lipton, S.A. and Nicotera, P., "Calcium, free radicals and excitotoxins in neuronal apoptosis", Cell Calcium 23:165-171, 1998. 38. Murphey, T.H. et al., "Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake", J. FASEB 6:1624-1633, 1990. 39. Fahn, S., "A pilot trial of high-dose alpha- tocopherol and ascorbate in early Parkinson's disease", Ann. Neurol. 32:$128-S132, 1992. 40. Niki, E., "Interactions of ascorbate and alpha-tocopherol", Third Conference of Vitamin C, Burns, E.T. (ed.), Ann. NY Acad. Sci. 498:186-199, 1987. 41. Beal, M.F., Hyman, B.T. and Koroschetz, W., "Do defects in mitochondrial energy metabolism underlie the pathology of neu- rodegenerative diseases?", Trends in Neurosci. 16:125-131, 1993. 42. Pall, H.S., Blake, D.R. et al., "Raised cere- brospinal fluid copper concentration in Parkinson's disease", Lancet Aug 1:238- 2411987. 43. Sorg, O., Horn, T.F. et al., "Inhibition of astrocyte glutamate uptake by reactive oxygen species: role of antioxidant enzymes", Mol. Med. 7:431-440, 1997. Editor's Note: This article is reproduced courtesy of Dr Russell Blaylock and was first published in Medical Sentinel (vol. 4, no. 6, Nov-Dec 1999), the bimonthly peer-reviewed journal of the Association of American Physicians and Surgeons (AAPS) [Hacienda Publishing, Inc., PO Box 13648, Macon, GA 31208-3648, USA, tel (912) 757 9873, fax (912) 757 9725, e-mail hfaria@mindspring.com, website www.haciendapub.com]. Continued next issue ... 82 - NEXUS JUNE — JULY 2000