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oo WATER + ALCOHOL + OPC FIGURE 3: WATER, ALCOHOL, WINE, OPC AND THE REBOUND EFFECT Renaud also tested red wine against a red | Pjatelet aggregation, comparing watertalcohol (2nd bar), red wine (3rd bar) and wine ‘replica’ made out of water, alcohol and | watert+alcohol+OPC (4th bar) to pure water (1st bar=100). Measurements were taken CEP's grape seed extract (OPC). The | amongst the test animals during regular intake (top), and in the rebound period, 18 hours inhibitory effect on platelet aggregation that after intake (bottom). During regular intake, aggregation drops for all three drinks. After continues during the hours after drinking 18 hours of deprivation, the water+alcoho! dramatically rebounds with a 124% increase, ” | while red wine and water+alcohol+OPC remain at the 59% decrease level, totally could be completely reproduced by the ‘replica’ that contained as much OPC as the escaping the Ieieiemms aire. red wine (0.03%). Due to the OPC, the rebound effect is completely undercut, while NON DEPRIVED platelet aggregation remains at the reduced level when the drinking stops. The OPC 100 REGULAR INTAKE stands for the difference between a 124% increase (water+alcohol) and a 59% decrease 80 (watertalcohol+OPC)}—a total difference of 183% } OPC KILLS PARADOX AND LETS 60 FRENCH LIVE LONGER No wonder that the French—at least the French wine-drinkers—have a 30% to 40% 40 lower risk for coronary heart disease than people who normally do not drink wine but liquor or beer. 20 The beneficial effect of wine has such an enormous impact on health statistics that, by early 1995, French women reached the high- 0 est life expectancy in the world—and the men are doing almost as well. Even though perhaps the whole scientific 300 DEPRIVED truth has not yet been established, we take FOR 18 HOURS our chances in saying that it must be the OPC that pushes French statistics to such 250 REBOUND healthy levels. OPC takes care of vascular integrity (biosynthesis, permeability and elasticity). It 200 also takes care of proper elimination of cho- lesterol and inhibition of cholesterol deposits on the vascular wall's elastin. In addition to 150 this, OPC inhibits formation of the plaque- forming cholesterol and the platelet aggrega- 100 tion rebound effect. And apart from that, OPC may well play a beneficial role against cancer. 50 RED WINE AND CANCER Although the relationship between wine 0 and cancer was not the subject of Dr Renaud's study, he alludes to this anti-cancer WATER WATER+ RED WATER+OPC effect where he mentions in his introduction ALCOHOL WINE +ALCOHOL that a moderate intake of wine was related to a protective effect of 20% to 50% in oral and pharyngeal cancers. fundamental substances surrounding tissues and cells. We know This effect was not shared by other alcoholic beverages. that OPC protects proteins against such proteolytic enzymes. For Masquelier confirms that the French scientific community is example, breast cancer is a type of cancer that spreads via sec- developing an intense interest in the relationship between wine, ondary tumours by producing proteolytic enzymes. So it seems OPC and cancer. logical to administer OPC as soon as breast cancer is diagnosed, to As one of the possible biological anti-cancer mechanisms that prevent secondary tumours developing. This would be a direct come into play, Masquelier explains that "it is widely known that —_ action of OPC against cancer. cancers will spread more rapidly and the number of secondary "I am not an oncologist. But I do think that it is one of the tumours will increase if the living organism is fatigued or stressed. applications of OPC which deserves to be more widely known. This is because of the organism's inability to offer resistance to the _I'm aware that in speaking of cancer, it is easy to instil false hope cancer cells. into cancer patients. Learning about a new medicine could well "Some types of cancer form invasive metastases (secondary _ revive all the lost hope. So it is the medical world that I am tumours) by secreting protein-splitting enzymes that dissolve the addressing." NON DEPRIVED REGULAR INTAKE DEPRIVED FOR 18 HOURS REBOUND fundamental substances surrounding tissues and cells. We know that OPC protects proteins against such proteolytic enzymes. For example, breast cancer is a type of cancer that spreads via sec- ondary tumours by producing proteolytic enzymes. So it seems logical to administer OPC as soon as breast cancer is diagnosed, to prevent secondary tumours developing. This would be a direct action of OPC against cancer. "I am not an oncologist. But I do think that it is one of the applications of OPC which deserves to be more widely known. I'm aware that in speaking of cancer, it is easy to instil false hope into cancer patients. Learning about a new medicine could well revive all the lost hope. So it is the medical world that I am addressing." NEXUS ¢« 29 WATER + ALCOHOL + OPC NON DEPRIVED REGULAR INTAKE FEBRUARY-MARCH 1996