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Acknowledgments Gountless colleagues, committees, and agencies helped with all stages xt of this research. Several deserve special mention. The late Daniel X. Freed- man, M.D., from UCLA's Department of Psychiatry, advocated for these projects at all levels and was instrumental in my obtaining crucial early funding. Staff at the U.S. Food and Drug Administration and the U.S. Drug Enforcement Administration were extraordinarily flexible and re- sponsive to the unusual circumstances of this research. Clifford Quails, Ph.D., the University of New Mexico biostatistician, spent endless hours, days, and weeks crunching numbers at the Research Center, at his home, and at mine. David Nichols, Ph.D., from Purdue University, made the DMT, without which the research never would have occurred. At every turn, the University of New Mexico School of Medicine pro- vided academic, physical, and administrative support for my work. Walter Winslow, M.D., chairman of the Department of Psychiatry, gave me great latitude as one of his only clinical research scientists at the time. Samuel Keith, M.D., continued with outstanding administrative and academic assistance and counsel after Dr. Winslow retired. Alan Frank, M.D., chair of the university's Human Research Ethics Committee, handled my re- quests with consistency and evenhandedness. To the UNM General Clinical Research Center I express my appre- ciation for their decade of assistance in all my studies: melatonin, DMT,