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found it. PSYCHEDELIC DRUGS: SCIENCE AND SOCIETY + 41 substances, and we know an enormous amount about them. They ushered in the modern era of biological psychiatry, and their highly publicized abuse prematurely ended an extraordinarily rich human research endeavor. It was into this seething matrix of conflict, ambivalence, and contro- versy that I looked for a point of traction and a clear line of sight in order to formulate my own research agenda. Where could I get a toehold? In which direction should I look? I needed a key with which to open the lock keeping psychedelic research buried. Out of this virtual swamp emerged one small obscure molecule: DMT. Its call was one I could not ignore, even though I had little idea of how I might get to it. Nor could I possibly expect where it would lead me once I