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Dedication 1. National Institutes of Health grants funded the melatonin project (RRO0997-10), the DMT and psilocybin studies (RO3 DA06524 and RO1 DA08096), and general operations of the Clinical Research Center (M01 RR00997). Prologue 1. The most direct way to get DMT into the brain, of course, is to inject it straight into this sensitive organ. I know of no studies in which researchers gave psychedelic drugs to humans in this manner. However, there is a report describing direct administration of LSD into the cerebrospinal fluid using a spinal tap. Since the cerebrospinal fluid bathes the brain, it allows direct access to it. In this case, LSD effects began "almost instantly." See Paul Hoch, "Studies in Routes of Administration and Counteracting Drugs," in Lyser- gicAcidDiethylamide and Mescaline in Experimental Psychiatry, edited by Louis Cholden (New York: Grune & Stratton, 1956), 8-12. 2. There were people who had used IV DMT in non-research, or recreational, settings. One of the men I interviewed in the process of developing the rating scale took it this way in the 1960s. His opinion was that it was "just slightly faster" than smoking it. 346 Notes 1. Jean Toomer and Rudolph P. Byrd, Essentials (Athens: University of Georgia Press, 1991), 27. Acknowledgments