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Stepping on Holy Toes 294 mn 1 here generally is little support for the incorporation of spirituality, with its nonmaterial and therefore non-measurable factors, into clinical research's fold. We will see in this chapter that neither is organized reli- gion, no matter how mystically inclined, open-minded and secure enough to seriously consider the spiritual potential of clinical research with psychedelics. There are several places in this book where I refer to my interest in Buddhist theory and practice. In addition to theoretical and practical con- tributions to the research, I also received much personal support and guidance from decades of involvement with an American Zen Buddhist monastery. From the initial inspiration for the psychedelic research to the development of the rating scale and our methods of supervising sessions, my understanding of Buddhism pervaded nearly every aspect of working with the spirit molecule.