Page Content (OCR)
xv Introduction In 19901 began the first new research in the United States in over twenty years on the effects of psychedelic, or hallucinogenic, drugs on humans. These studies investigated the effects of N,N-dimethyltryptamine, or DMT, an extremely short-acting and powerful psychedelic. During the project's five years, I administered approximately four hundred doses of DMT to sixty human volunteers. This research took place at the University of New Mexico's School of Medicine in Albuquerque, where I was tenured Asso- ciate Professor of Psychiatry. I was drawn to DMT because of its presence in all of our bodies. I believed the source of this DMT was the mysterious pineal gland, a tiny organ situated in the center of our brains. Modern medicine knows little about this little gland's role, but it has a rich "metaphysical" history. Descartes, for example, believed the pineal was the "seat of the soul," and both Western and Eastern mystical traditions place our highest spiri- tual center within its confines. I therefore wondered if excessive pineal DMT production was involved in naturally occurring "psychedelic" states. These might include birth, death and near-death, psychosis, and mystical experiences. Only later, when the study was well underway, did I also begin considering DMT's role in the "alien abduction" experience. The DMT project was founded on cutting-edge brain science, espe- cially that which dealt with the psychopharmacology of serotonin. However,