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Acknowledgments ¢ xiii Carol and Rodney Houghton, Daniel Hoyer, Oscar Janiger, David Janowsky, Karl Jansen, Sheperd Jenks, Robert Jesse, Robert Kellner, Herbert Kleber, Tad Lepman, Nancy Lethcoe, Paul Lord, David Lorimer, Luis Eduardo Luna, John Mack, Dennis and Terence McKenna, Herbert Meltzer, David Metcalf, Ralph Metzner, Nancy Morrison, Ethan Nadelmann, Ken Nathanson, Steven Nickeson, Oz, Bernd Michael Pohlman, Karl Pribram, Jill Puree, Rupert Sheldrake, Alexander and Ann Shulgin, Daniel Siebert, Wayne Silby, Zachary Solomon, Myron Stolaroff, Juraj and Sonja Styk, Steven Szara, Charles Tart, Requa Tolbert, Tarthang Tulku, Joe Tupin, Eberhard Uhlenhuth, Andrew Weil, Samuel Widmer, and Leo Zeff. My former wife, Marion Cragg, was there for me and the research through all its twists and turns, providing valuable advice and counsel. Several people additionally read all or part of the manuscript and commented liberally and helpfully on the work-in-progress: Robert Barnhart, Rick Doblin, Rosetta Maranos, Tony Milosz, Norm Smookler, Andrew Stone, Robert Weisz, and Bernard Xolotl. Many thanks to Daniel Perrine for rendering the best possible images of the book's molecular structures. And to Alex Grey, deep appreciation for the cover art, and for leading me to Inner Traditions, where Jon Graham liked what he saw in my proposal. Rowan Jacobsen has been everything an editor can be, and then some. Nancy Ringer's peerless copyediting made many improvements to the text. lam grateful to my former Zen Buddhist community's late abbot, and to the monastic and extended lay communities for their teaching, guid- ance, and a powerful model of mystical pragmatism. My deepest thanks go to my family, for without my parents, Alvin and Charlotte Strassman; my brother, Marc Strassman; and my sister, Hanna Dettman, none of this would have been possible. Finally, I salute, bow, and stand in awe of the volunteers. Their courage to hitch themselves to the spirit molecule's wings, their faith in the research team watching over their bodies and minds while they ventured forth, and their grace under the most austere and unforgiv- ing environment imaginable for taking psychedelic drugs will serve as an inspiration for generations of fellow seekers.