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1510 King Ferdinand consents to recruitment of the first large contingent of African slaves in the grow- ing Spanish sugar industry. 1526 From 1526 to 1546, there was a tendency for syphilis to become milder and more chronic in nature. 1578 First recognized description of whooping cough (Pertussis) by French physician Guillame Baillou during epidemic i in Paris. 1601 Jesuits establish mission in Beijing, China, to provide contacts for the Portuguese and Dutch for access to native drug trafficking routes in the East. The Dutch negotiate an opium monopoly for north- ern India. 1606 London Company chartered to establish the Virginia Plantation on a communistic basis, and the Plymouth Company, whose descendants would control the New England business world. 1627 Francis Bacon writes The New Atlantis, which espouses the paradigm of a world university that scans the world for talented children in order to enrich the power of the state, because the state will know everything and be invincible. The book is widely read by Germans mystics. 321 Appendix F: General Chronology of Events 1497 Vasco da Gama carries syphilis to India. 1498 Syphilis outbreak in India. 1500 Epidemic of syphilis. 1500 Dutch establish a sugar refinery at Antwerp and ships sugar to Germany and England. 1501 Swift development of book printing and typography. 1505 Syphilis outbreak reaches Canton, China. 1509 First attempts to restrict right to practice medicine to licensed doctors. 1515 Spanish monks offer loans in gold to anyone who would start a sugar mill. 1528 Severe outbreaks of plague in England. 1533 First non-medical insane asylums instituted. 1557 Massive influenza epidemic in Europe. 1558 Tobacco first brought to Europe from Mexico. 1560 Charles V of Spain builds vast palaces using taxes on sugar trade 1563 General outbreak of plague in Europe. Kills 20,000 in London. 1567 In South America, 2 million die from typhoid fever. 1568 Disease epidemic in Lisbon kills 40,000. 1573 First German sugar cane refinery at Augsburg. 1592 Plague kills 15,000 people in London. 1599 Outbreak of plague in Spain. 1600 East India Company granted a charter by the Queen of England. 1603 Heavy outbreak of plague in England. 1607 Announcement of national bankruptcy in Spain. 1608 Telescope discovered. 1612 Tobacco planted in Virginia in American colonies. 1622 Under James I, the East India Company becomes a joint stock company. Atlantis, Alien Visitation, and Genetic Manipulation