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The Scale of Things - Nanometers and More *rhings Natural Dust mite <—_> 200 pum Human hair ~ 60-120 jum wide ~ 10-20 pm Red blood cells…
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Potential Hazards * Toxic potential of novel nanoparticles is uncertain + Many variables may effect toxicity: — size — shape — chemistry —…
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Potential Hazards Drivers of toxicity include: + Intrinsic elemental (chemical) toxicity - Lead, cadmium, etc. - Semiconductor nanocrystals…
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Potential Hazards * Large particles that are minimally toxic - may become more toxic at the nanoscale: a KE - Apparent pulmonary toxicity…
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Potential Hazards Particle Size Dependent Toxicity Is Not New * Crystalline silica — respirable fraction most toxic when for two reasons: —…
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Potential Hazards Ultrafine (Nano) Particulate Air Pollution is Associated With Disease + Nanoparticles in air pollution are associated…
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Potential Hazards * Some nanoparticles bypass barriers to distribution and travel — into bloodstream / passing through respiratory or…
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Potential Hazards Summary: * Toxicity may be highly dependent on many variables - difficult to generalize « At the nanoscale: - Non-toxic…
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Safe Work Practices
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Safe Work Practices SLAC follows* a prudent approach to handling nanomaterials of unknown toxicity and reactivity: * Assume all…
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Safe Work Practices Nanomaterial Safety Plan* * Component of SLAC Environment, Safety, and Health Manual, Chapter 40, “Hazardous Materials”…
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vay Cll Ve A 2 \3 4) } yS ] \ wy OWS ky | Y am \ QS RATIONAWACCELERATOR UAB ORATOR ATES SS Nanomaterial Laboratory Safety ES&H Course 161…
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Safe Work Practices Assigned risk-level determines: required review / approval & controls: Proposal Reviewed */ Controls and Work Approved…
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Safe Work Practices Consistent with research needs, handle nanoparticles in the least dispersible form possible: Best: attached to…
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Safe Work Practices When nanoparticles suspended in liquids are brought to the beam line or transported internally they must be: —…
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Safe Work Practices Administrative controls: Housekeeping * Maintain all working surfaces free of nanoparticles contamination — Wipe…
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Safe Work Practices Administrative controls: Labeling and Storage — Label storage containers of nanoparticles to indicate both the chemical…
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Safe Work Practices Administrative controls: Work Area Signage Creating a Safe, Secure and Sustainable Environment for Science Work area…
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Safe Work Practices Personal Protective Equipment — Follow laboratory safe operating procedures maintained by the Laboratory Manager &…
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Safe Work Practices Personal Protective Equipment: Respirators — Respirators or filtering facemasks should not be required* — If you think…
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Safe Work Practices Transportation of Nanomaterials from SLAC to and from off-site locations: — If hazardous per 49 CFR * Must be packaged,…
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Safe Work Practices Nanomaterial Waste — Both regulated (classified as hazardous per 40 CFR) and unregulated waste containing nanoparticles…
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Course Purpose and Objectives Nanomaterials and their unique size-dependant properties are of considerable scientific interest - * Course…
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Safe Work Practices Emergency and Spill Procedures - Access Control - restrict entry to affected area with barricade tape or another…
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Safe Work Practices Medical Health Surveillance + Baseline medical evaluation* Offered to SLAC staff identified as: — nanoparticle workers…
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References — Hazards, Safe Handling, Storage + Department of Energy, Nanoscale Science Research Centers, Approach to Nanomaterial ES&H…
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Ehe New York Times nytir ‘ January 14, 2007 BERKELEY LEGAL Teeny-Weeny Rules for Itty-Bitty Atom Clusters By BARNABY J. FEDER See attached…
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Section 3: Controls for Research Laboratory Operations Table 1 Requirements by Risk / Material Form Nanomaterial Safety Plan Risk /…
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Section 3: Controls for Research Laboratory Operations Nanomaterial Safety Plan Risk / Material Form Medium Requirements Nanoparticles…
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Nanomaterial Safety Plan Section 3: Controls for Research Laboratory Operations Requirements Risk / Material Form 1. _Weste containers: a…
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What are nanomaterials? Engineered nanoparticles * intentionally created (in contrast with natural or incidentally formed) particle with…
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What are nanomaterials? DOE Definition = Unbound Engineered Nanoparticle (UNP) * Engineered nanoparticles not contained within a matrix =>…
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Nanomaterials Are Not New We have been exposed to natural and man-made nanoscale particles for years: — Diesel exhaust Welding fumes Carbon…
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Potential for Novel Toxicity and Reactivity * The properties of nanoscale materials may be significantly different from bulk materials of…
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Potential Hazards
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Potential Hazards Concern is centered on “Unbound Nanoparticles” which are: * Not firmly attached to a surface + Not part of a bigger item…