imece_nano_tox_contour_page_1
SELECTING NANOPARTICLE PROPERTIES TO MITIGATE RISKS TO WORKERS AND THE PUBLIC — A MACHINE LEARNING MODELING FRAMEWORK TO COMPARE PULMONARY…
imece_nano_tox_contour_page_10
Funding for this research was provided by the National Science Foundation (NSF) and the Environmental Protection Agency (EPA) under NSF…
imece_nano_tox_contour_page_11
25 26 27 28 29 30 31 32 33 34 35, 36 37 38 carbon nanotubes in C57BL/6 mice,” Toxicol. Appl. Pharmacol., 221(3), pp. 339-348. Warheit D.…
imece_nano_tox_contour_page_12
ANNEX A NANOPARTICULATE TOXICITY RISK CONTOUR PLOTS This annex contains additional toxicity risk contour plots generated by the random…
imece_nano_tox_contour_page_13
BAL TP (fold of control) MMAD' recovery time (days) Figure A5: Changes in RF model predicted BAL total protein following exposure to…
imece_nano_tox_contour_page_14
avg size (nm) LDH (fold of control) 10° 15 0.5 O 2000 4000 6000 8000 10000 12000 14000 16000 Cale Total Dose, mass (ug/kg) Figure A9:…
imece_nano_tox_contour_page_15
ANNEX B DETAILS ON RANDOM FOREST MODEL STRUCTURE AND LEARNING This annex contains details on the random forest model structures employed in…
imece_nano_tox_contour_page_16
x 10° RF Variable Importance: LDH (fold of control) RF Variable Importance: BAL LDH (fold of control) 0.35 HEE positive 16 [EE Dregative HE…
imece_nano_tox_contour_page_17
100. Model Error Random Forest Model Learning Progression These figures display the error of the RF model in predicting the actual observed…
imece_nano_tox_contour_page_18
15- 4 Model Error 0.5, 4 °o 400 200 300 400 500 600 700 800 900 1000 Number of Trees Included in Model Figure B10: RF model error as a…
imece_nano_tox_contour_page_19
ANNEX C TABLE OF DATA SOURCES Table C-1: Listing of all rodent pulmonary toxicity studies included in this meta-analysis. Recovery…
imece_nano_tox_contour_page_2
characteristics as particle size increases. Conversely, at small sizes, particles can exhibit an entirely new property like semi-…
imece_nano_tox_contour_page_3
procedure where saline fluid is used to rinse out the lungs of the rodent some time following exposure. The fluid is collected along with…
imece_nano_tox_contour_page_4
Total Dose (ug/kg) <5150 Y = 32.54 88.9 N=525 inequality is inequality is true false Y =20.3 + 44.2 Y = 375+ 233 N=345 N=180 Figure 1:…
imece_nano_tox_contour_page_5
Neutrophils (fold of control) BAL LDH (fold of control) 200 1.72 200 17 180 180 1.68 160 160 1.66 > @ 140 g 40 $ 1.64 = = 120 g 120 2 1.62…
imece_nano_tox_contour_page_6
length median (nm) length median (nm) Minimum Dose Median Dose Maximum Dose 6 5.5 Is 4.5 la 3.5 3 2.5 2 1.5 a 5 10 15 20 2 30 35 40 45 5 10…
imece_nano_tox_contour_page_7
Minimum Dose Median Dose Maximum Dose = 2 5 a 800 1000 1200 1400 600 800 1000 1200 1400 200 g00 1000 1200 1400 MMAD" Minimum Dose Median…
imece_nano_tox_contour_page_8
Gibbs Free Energy (kJ/mol) Minimum Dose Median Dose Maximum Dose x 10° -350 a5 -400 3 -450 -500 25 -550 2 -600 -650 15 -700 1 -750 -800 Os…
imece_nano_tox_contour_page_9
When considering the metal oxides as a group, particle size does affect the BAL concentration of LDH to some extent, with larger particles…