PIHKALAnthologyShulgin_page_801

PIHKALAnthologyShulgin | page 801 | https://thedailydialectics.com/pdfs/education/chemistry/phenylethylenes/PIHKALAnthologyShulgin/PIHKALAnthologyShulgin.pdf

For the preparation of MIPM, the above phenol, 2,5-dimethoxyphenol was isopropylated with isopropyl bromide in methanolic KOH giving 2,5-dimethoxy- 1-(i)-propoxybenzene as an oil. This formed the benzaldehyde with the standard Vilsmeier conditions, which melted at 77-78 !C from hexane and which…